The reference site for Midazolam

Midazolam, marketed under the trade name Versed, among others, is a medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation.

WHAT IS Midazolam?

Midazolam is used to produce sleepiness or drowsiness and to relieve anxiety before surgery or certain procedures. It is also used to produce loss of consciousness before and during surgery.

Additionally, this medication is sometimes used in patients in intensive care units in hospitals. It allows the patients to withstand the stress of being in the intensive care unit and help them cooperate when a machine must be used to assist them with breathing.

 

Brand Name(s): Versed; Sedoz
CAS nº: 59467-70-8
(MID-ay-zoe-lam)

 

Product Info

The sections below will provide you with more specific information and guidelines related to midazolam and its correct use. Please read them carefully.

FDA Information

Midazolam was first synthesized in 1976 by Fryer and Walser, and later approved by the FDA in 1985. A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Midazolam is a benzodiazepine. Benzodiazepines belong to a group of medicines that slow down the central nervous system.

This medication is a sedative hypnotic that causes relaxation and sleep. In anesthesia it provides loss of awareness and memory for short diagnostic tests and surgical procedures, produces sleep at the beginning of surgery, or supplements other types of general anesthetics.

Other uses for this medicine

Midazolam may also be used to treat certain seizures.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

USAGE

Midazolam is given only by or under the immediate supervision of a doctor trained to use this medicine. If you are to receive midazolam during surgery, your doctor or anesthesiologist will give you the medicine and closely follow your progress.

Midazolam is available in either an oral solution or as an injection.

DOSAGE

The dose of midazolam will vary for different patients. Your doctor will decide on the right amount for you. The dose normally depends on:

– your age
– your weight
– general physical condition,
– the kind of surgery or other procedure you are having
– other medicines you are taking or will receive before and during the procedure

What special precautions should I follow?

BEFORE TAKING MIDAZOLAM:

In deciding to use a particular medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will need to make. For midazolam, the following should be considered:

ALLERGIES – Tell your doctor if you have ever had any unusual or allergic reaction to midazolam or other benzodiazepines (such as alprazolam [e.g. Xanax®], bromazepam [e.g. Lectopam®], chlordiazepoxide [e.g. Librium®], clonazepam [e.g. Klonopin®], clorazepate [e.g. Tranxene®], diazepam [e.g. Valium®], estazolam [e.g. ProSom®], flurazepam [e.g. Dalmane®], halazepam [e.g. Paxipam®], ketazolam [e.g. Loftran®], lorazepam [e.g. Ativan®], nitrazepam [e.g. Mogadon®], oxazepam [e.g. Serax®], prazepam [e.g. Centrax®], quazepam [e.g. Doral®], temazepam [e.g. Restoril®], triazolam [e.g. Halcion®]). Also, tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

PREGNANCY – Midazolam is not recommended for use during pregnancy because it may cause birth defects. Other benzodiazepines, such as chlordiazepoxide (e.g. Librium®) and diazepam (e.g. Valium®) that are related chemically and in action to midazolam, have been reported to increase the chance of birth defects when used during the first 3 months of pregnancy. Also, use of midazolam during pregnancy, especially during the last few days, may cause drowsiness, slow heartbeat, shortness of breath, or troubled breathing in the newborn infant. In addition, receiving midazolam just before or during labor may cause weakness in the newborn infant.

BREAST-FEEDING – Midazolam passes into human breast milk. Because newborn babies may be especially sensitive to the effects of midazolam, you should discuss breast-feeding with your physician if you are going to receive midazolam. It may be advisable to stop breast-feeding for a short period of time after receiving midazolam.

CHILDREN – Newborn babies may be especially sensitive to the effects of midazolam. This may increase the chance of side effects during the use of this medicine. Also, time to complete recovery after midazolam is given may be longer in very ill newborn babies.

OLDER ADULTS – Elderly people are especially sensitive to the effects of midazolam. This may increase the chance of side effects during the use of this medicine. Also, time to complete recovery after midazolam is given may be slower in the elderly than in younger adults.

OTHER MEDICATION – Although certain medicines should not be used together at all, in some cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving midazolam, it is especially important that your health care professional knows if you are taking any of the following:

Central nervous system (CNS) depressants (medicines that cause drowsiness) or alcohol. The CNS depressant and other effects of alcohol, other medicines, or midazolam may be increased. Moreover, the effects of midazolam may last longer than required.

Saquinavir (e.g. Fortovase®, Invirase®). Saquinavir may interfere with the removal of midazolam from the body, which could lead to serious side effects.

– Other medical problems. The presence of other medical problems may affect the use of midazolam. Make sure you tell your doctor if you have any other medical problems, especially:

* Heart disease
* Kidney disease
* Liver disease
* Obesity (the effects of midazolam may last longer).
* Lung disease
* Myasthenia gravis or other muscle and nerve disease (midazolam may make   the condition worse).

For patients going home within 24 hours after receiving midazolam:

Midazolam may cause some people to feel drowsy, tired, or weak for 1 or 2 days after it has been given. It may also cause problems with coordination and one’s ability to think. Therefore, do not drive, use machines, or do anything else that could be dangerous if you are not alert until the effects of the medicine have disappeared or until the day after you receive midazolam, whichever period of time is longer.

Do not drink alcoholic beverages or take other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness) for about 24 hours after you have received midazolam, unless otherwise directed by your doctor. To do so may add to the effects of the medicine. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, colds, other sedatives, tranquilizers, sleeping medicine, prescription pain medicine or narcotics, medicine for seizures, and muscle relaxants.

What should I do if I forget a dose?

If you miss a dose, contact your doctor to establish a new dosing schedule.

NEVER double-up the doses.

What side effects can this medication cause?

While you are receiving midazolam your doctor will monitor you closely for the side effects of midazolam, for example, breathing problems and confusion.

Some side effects may occur that usually do not need medical attention. Most side effects will go away as the effects of midazolam wear off.

However, check with your doctor if any side effects continue or are especially bothersome.

What storage conditions are needed for this medicine?

Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture.

Remember to throw away any medication that is outdated or no longer needed. If necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of overdose may include:

somnolence (difficulty staying awake)
mental confusion
hypotension
impaired motor functions (impaired reflexes, impaired coordination, impaired balance, or dizziness)
coma

Product Images

PICTURES OF midazolam PILLS

Below you will find images and specific information on the principal types of midazolam that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: MIDAZOLAM
Strength(s): 2 MG / 2 ML
Imprint: MIDAZOLAM HCL INJECTION
Manufacturer: ROCHE

Name: MIDAZOLAM
Strength(s): 5 MG / 5 ML
Imprint: MIDAZOLAM
Manufacturer: APOTEX INC.

Name: SEDOZ®
Strength(s): 5 MG / ML
Imprint: MIDAZOLAM INJECTION BP
Manufacturer: CLARIS

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